ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene.[5][6]
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.[6]
It prevents ATPase from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [7] ATP synthase inhibitor forms a one-to-one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP.[8] The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH, the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity.[7]
| Mitochondrial ATPase inhibitor, IATP | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 c-terminal coiled-coil domain from bovine if1 | |||||||||
| Identifiers | |||||||||
| Symbol | IATP | ||||||||
| Pfam | PF04568 | ||||||||
| InterPro | IPR007648 | ||||||||
| SCOP2 | 1hf9 / SCOPe / SUPFAM | ||||||||
| |||||||||
References
External links
- Human ATPIF1 genome location and ATPIF1 gene details page in the UCSC Genome Browser.