AKAP5

AKAP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H9R, 3LL8
Identifiers
Aliases	AKAP5, AKAP75, AKAP79, H21, A-kinase anchoring protein 5
External IDs	OMIM: 604688; MGI: 2685104; HomoloGene: 15854; GeneCards: AKAP5; OMA:AKAP5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	64,474,503 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	76,380,927 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; entorhinal cortex; ; superior frontal gyrus; ; postcentral gyrus; ; nucleus accumbens; ; primary visual cortex; ; endothelial cell; ; caudate nucleus; ; prefrontal cortex;
	Top expressed in
	left lung lobe; ; olfactory tubercle; ; nucleus accumbens; ; right lung; ; right lung lobe; ; lateral septal nucleus; ; globus pallidus; ; temporal lobe; ; Region I of hippocampus proper; ; amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase A binding; calmodulin binding; protein binding; protein kinase A regulatory subunit binding; adenylate cyclase binding; SH3 domain binding; protein phosphatase 2B binding; beta-2 adrenergic receptor binding; molecular adaptor activity; glutamate receptor binding; GABA receptor binding; scaffold protein binding;
Cellular component	cytosol; membrane; plasma membrane; cytoplasmic side of plasma membrane; postsynaptic density; dendrite membrane; dendritic spine; membrane raft; excitatory synapse; intracellular anatomical structure;
Biological process	protein targeting; signal transduction; positive regulation of protein kinase A signaling; chemical synaptic transmission; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; regulation of protein kinase A signaling; positive regulation of adenylate cyclase activity; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	9495
	238276
	ENSG00000179841
	ENSMUSG00000021057
	P24588; Q6PG46
	D3YVF0
	NM_004857
	NM_001101471
	NP_004848; NP_004848.3
	NP_001094941
	Wikidata
View/Edit Human	View/Edit Mouse

A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.^[5]^[6]^[7]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.^[7]

Interactions

AKAP5 has been shown to interact with:

Calcineurin^[8] and
GABRB3.^[9]

References

External links

Human AKAP5 genome location and AKAP5 gene details page in the UCSC Genome Browser.

Search

AKAP5

Contents

Function

Interactions

References

External links

Further reading