The 2010 AFC Cup was the 7th edition of the competition, played between clubs from nations who are members of the Asian Football Confederation. The Knockout stage of the competition was held following the completion of the Qualifying competition.
Bracket
Note: while the bracket below shows the entire knockout stage, the draw for the round of 16 matches was determined at the time of the group draw.
The draw for the quarter-finals and beyond was held separately, after the conclusion of the round of 16. Because of the country protection rule, if there are two clubs from the same country, they will not face each other in the quarter-finals. Therefore, the two clubs from Syria, Kuwait, and Thailand may not be drawn with each other in the quarter-finals.[1]
| Round of 16 | Quarter-finals | Semi-finals | Final | ||||||||||||||||
 Al-Karamah | 1 | ||||||||||||||||||
 Nasaf Qarshi | 0 | ||||||||||||||||||
| Al-Karamah | 1 | 0 | 1 | ||||||||||||||||
 Muangthong United | 0 | 2 | 2 | ||||||||||||||||
 Al-Rayyan | 1 (2) | ||||||||||||||||||
| Muangthong United (p) | 1 (4) | ||||||||||||||||||
| Muangthong United | 1 | 0 | 1 | ||||||||||||||||
| Al-Ittihad | 0 | 2 | 2 | ||||||||||||||||
 Al-Kuwait | 1 (4) | ||||||||||||||||||
| Al-Ittihad (p) | 1 (5) | ||||||||||||||||||
| Al-Ittihad | 3 | 1 | 4 | ||||||||||||||||
| Kazma | 2 | 0 | 2 | ||||||||||||||||
| Kazma (p) | 1 (6) | ||||||||||||||||||
 Shabab Al-Ordon | 1 (5) | ||||||||||||||||||
| Al-Ittihad | 1 (4) | ||||||||||||||||||
| Al-Qadsia | 1 (2) | ||||||||||||||||||
 Al-Riffa | 3 | ||||||||||||||||||
 South China | 1 | ||||||||||||||||||
| Al-Riffa | 3 | 5 | 8 | ||||||||||||||||
 SHB Đà Nẵng | 0 | 3 | 3 | ||||||||||||||||
| SHB Đà Nẵng (a.e.t.) | 4 | ||||||||||||||||||
| Bình Dương | 3 | ||||||||||||||||||
| Al-Riffa | 2 | 1 | 3 | ||||||||||||||||
| Al-Qadsia | 0 | 4 | 4 | ||||||||||||||||
 Sriwijaya | 1 | ||||||||||||||||||
| Thai Port | 4 | ||||||||||||||||||
| Thai Port | 0 | 0 | 0 | ||||||||||||||||
| Al-Qadsia | 0 | 3 | 3 | ||||||||||||||||
| Al-Qadsia (a.e.t.) | 2 | ||||||||||||||||||
 Churchill Brothers | 1 | ||||||||||||||||||
Round of 16
| South China | 1 – 3 | Al-Riffa |
|---|---|---|
Lee Chi Ho  28' | Report | Mubarak 15' Habib 18'Abdullatif 82' |
| Al-Rayyan | 1 – 1 (a.e.t.) | Muangthong United |
|---|---|---|
| Alves 41' (pen.) | Report | Dangda 17' |
| Penalties | ||
Abdi  Naji  Ismail Goma | 2 – 4 | Jitsawad Tamaphan Thonglao Choeichiu Dangda |
| Kazma | 1 – 1 (a.e.t.) | Shabab Al-Ordon |
|---|---|---|
| Al-Sulaiman 68' | Report | Kapolongo 45+1' |
| Penalties | ||
| Al-Shammari Al-Hamad Al-Sulaiman Sandro Andic Al-Waheeb | 6 – 5 | Saleh Nimer Mohannad Maharmeh Mohammad Khair Anas Al-Jbarat Ammar Al-Sharaideh Waseem Al-Bzour |
| Al-Karamah | 1 – 0 | Nasaf Qarshi |
|---|---|---|
| Abbas 76' (pen.) | Report |
| SHB Đà Nẵng | 4 – 3 (a.e.t.) | Bình Dương |
|---|---|---|
| Merlo 31', 97' Phan Duy Lâm 80'Đoàn Hùng Sơn 120' | Report | Nguyễn Anh Đức 63' Philani 84'Kesley 108' |
| Al-Qadsia | 2 – 1 | Churchill Brothers |
|---|---|---|
| Al-Enezi 34', 43' | Report | Okolie 61' |
Quarter-finals
First leg
| Al-Karamah | 1 – 0 | Muangthong United |
|---|---|---|
| Al Zeno 64' | Report |
| Al-Ittihad | 3 – 2 | Kazma |
|---|---|---|
| Dakka 45' (pen.) Al Ghabash 62'Shahrour 90' | Report | Aldafeeri 73' Laheeb 90+4' |
Second leg
| SHB Đà Nẵng | 3 – 5 | Al-Riffa |
|---|---|---|
| Merlo 15', 45' (pen.), 80' | Report | Salman 9', 52' Al Anezi 57'Abuda 72'Mubarak 90' |
Al-Riffa won 8–3 on aggregate.
| Muangthong United | 2 – 0 | Al-Karamah SC |
|---|---|---|
| Thonglao 28' Dagno 38' (pen.) | Report |
Muangthong United won 2–1 on aggregate.
Al-Qadsia won 3–0 on aggregate.
| Kazma | 0 – 1 | Al-Ittihad |
|---|---|---|
| Report | Hemidi 39' (pen.) |
Al-Ittihad won 4–2 on aggregate.
Semi-finals
First leg
| Muangthong United | 1 – 0 | Al-Ittihad |
|---|---|---|
| Dagno 9' | Report |
Second leg
Al-Qadsia won 4–3 on aggregate.
| Al-Ittihad | 2 – 0 | Muangthong United |
|---|---|---|
| Al Hasan 27', 41' | Report |
Al-Ittihad won 2–1 on aggregate.
Final
| Al-Qadsia | 1 – 1 (a.e.t.) | Al-Ittihad |
|---|---|---|
| Al-Enezi 29' | Report | Dyab 53' |
| Penalties | ||
| (penalty takers may not be in correct order) Al Ansari Al Bloushi Al Khatib Al Mejmed | 2–4 | (penalty takers may not be in correct order) Hemidi Dyab Dakka Kalaji |