Bracket
Note: while the bracket below shows the entire knockout stage, the draw for the round of 16 matches was determined at the time of the group draw, and kept teams from East and West Asia completely separate for that round.
The draw for the quarter-finals and beyond was held separately, after the conclusion of the round of 16. Because of the country protection rule, if there are two clubs from the same country, they will not face each other in the quarter-finals. Therefore, the two clubs from Saudi Arabia may not be drawn with each other in the quarter-finals. However, the same rule does not apply if there are more than two clubs from the country. Therefore, the four clubs from the Korea Republic may be drawn against each other in the quarter-finals.[1]
| Round of 16 | Quarter-finals | Semi-finals | Final | ||||||||||||||||
 Adelaide United | 2 | ||||||||||||||||||
 Jeonbuk Motors (a.e.t.) | 3 | ||||||||||||||||||
| Jeonbuk Hyundai Motors | 0 | 1 | 1 | ||||||||||||||||
 Al-Shabab | 2 | 0 | 2 | ||||||||||||||||
| Al-Shabab | 3 | ||||||||||||||||||
 Esteghlal | 2 | ||||||||||||||||||
| Al-Shabab | 4 | 0 | 4 | ||||||||||||||||
| Seongnam Ihwa (a) | 3 | 1 | 4 | ||||||||||||||||
| Seongnam Ilhwa Chunma | 3 | ||||||||||||||||||
 Gamba Osaka | 0 | ||||||||||||||||||
| Seongnam Ilhwa Chunma | 4 | 0 | 4 | ||||||||||||||||
| Suwon Samsung Bluewings | 1 | 2 | 3 | ||||||||||||||||
| Suwon Samsung Bluewings | 2 | ||||||||||||||||||
 Beijing Guoan | 0 | ||||||||||||||||||
| Seongnam Ilhwa Chunma | 3 | ||||||||||||||||||
| Zob Ahan | 1 | ||||||||||||||||||
| Zob Ahan | 1 | ||||||||||||||||||
| Mes Kerman | 0 | ||||||||||||||||||
| Zob Ahan | 2 | 1 | 3 | ||||||||||||||||
| Pohang Steelers | 1 | 1 | 2 | ||||||||||||||||
| Kashima Antlers | 0 | ||||||||||||||||||
| Pohang Steelers | 1 | ||||||||||||||||||
| Zob Ahan | 1 | 1 | 2 | ||||||||||||||||
| Al-Hilal | 0 | 0 | 0 | ||||||||||||||||
| Al-Hilal | 3 | ||||||||||||||||||
 Bunyodkor | 0 | ||||||||||||||||||
| Al-Hilal (a.e.t.) | 3 | 2 | 5 | ||||||||||||||||
 Al-Gharafa | 0 | 4 | 4 | ||||||||||||||||
| Al-Gharafa | 1 | ||||||||||||||||||
| Pakhtakor | 0 | ||||||||||||||||||
Round of 16
The draw for the round of 16 of the 2010 AFC Champions League was held on 7 December 2009, along with the draw for the group stage.
West Asia
| Al-Gharafa | 1–0 | Pakhtakor |
|---|---|---|
Araújo  86' (pen.) | Report |
| Zob Ahan | 1–0 | Mes Kerman |
|---|---|---|
| Igor 85' | Report |
| Al-Hilal | 3–0 | Bunyodkor |
|---|---|---|
| Al-Marshedi 9' Wilhelmsson 57'Neves 61' | Report |
East Asia
| Seongnam Ilhwa Chunma | 3–0 | Gamba Osaka |
|---|---|---|
| Molina 74' (pen.), 90' Song Ho-Young 84' | Report |
| Suwon Samsung Bluewings | 2–0 | Beijing Guoan |
|---|---|---|
| José Mota 27', 86' | Report |
| Adelaide United | 2–3 (a.e.t.) | Jeonbuk Hyundai Motors |
|---|---|---|
| Cornthwaite 78' van Dijk 90+5' | Report[dead link] | Eninho 38', 88' Lee Dong-Gook 116' |
Quarter-finals
First leg
| Jeonbuk Hyundai Motors | 0–2 | Al-Shabab |
|---|---|---|
| Report | Al Yamani 68' Olivera 90' |
| Seongnam Ilhwa Chunma | 4–1 | Suwon Samsung Bluewings |
|---|---|---|
| Radončić 8', 66' Molina 33'Yang Sang-Min 82' (o.g.) | Report | Yeom Ki-Hun 17' |
| Zob Ahan | 2–1 | Pohang Steelers |
|---|---|---|
| Igor 18' Rajabzadeh 76' (pen.) | Report | Mota 56' |
| Al-Hilal | 3–0 | Al-Gharafa |
|---|---|---|
| Al-Shalhoub 13' Al-Fraidi 59'Al-Gizani 85' | Report |
Second leg
| Pohang Steelers | 1–1 | Zob Ahan |
|---|---|---|
| Kim Jae-Sung 10' | Report | Khalatbari 80' |
Zob Ahan won 3–2 on aggregate.
Seongnam Ilhwa Chunma won 4–3 on aggregate.
| Al-Gharafa | 4–2 (a.e.t.) | Al-Hilal |
|---|---|---|
| Al Zain 2' Mahmoud 38', 102' El Assas 41' | Report | Al-Qahtani 117' Al-Mehyani 119' |
Al-Hilal won 5–4 on aggregate.
Al-Shabab won 2–1 on aggregate.
Semi-finals
First leg
| Al-Shabab | 4–3 | Seongnam Ilhwa Chunma |
|---|---|---|
| Olivera 15', 83' Nasser 56' Fisal 89' | Report | Molina 4', 68' Jo Jae-Cheol 26' |
Second leg
4–4 on aggregate. Seongnam Ilhwa Chunma won on away goals.
Zob Ahan won 2–0 on aggregate.
Final
| Seongnam Ilhwa Chunma | 3–1 | Zob Ahan |
|---|---|---|
| Saša 29' Cho Byung-Kuk 53'Kim Cheol-Ho 83' | Report | Khalatbari 67' |