Arrestin beta 2

Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.

ARRB2
Identifiers
Aliases	ARRB2, ARB2, ARR2, BARR2, Arrestin beta 2
External IDs	OMIM: 107941; MGI: 99474; HomoloGene: 3183; GeneCards: ARRB2; OMA:ARRB2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,710,596 bp[1] End 4,721,499 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.99 cM Start 70,323,461 bp[2] End 70,331,654 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right lung spleen right hemisphere of cerebellum upper lobe of left lung blood bone marrow cells right frontal lobe C1 segment Top expressed in granulocyte tibiofemoral joint thymus dentate gyrus of hippocampal formation granule cell stroma of bone marrow lymph node blood spleen mesenteric lymph nodes neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-1B adrenergic receptor binding 14-3-3 protein binding protein kinase B binding protein binding enzyme binding angiotensin receptor binding molecular adaptor activity signaling receptor binding G protein-coupled receptor binding ubiquitin protein ligase binding identical protein binding arrestin family protein binding protein-containing complex binding protein domain specific binding alpha-1A adrenergic receptor binding type 1 angiotensin receptor binding D1 dopamine receptor binding follicle-stimulating hormone receptor binding type 2A serotonin receptor binding platelet activating factor receptor binding mitogen-activated protein kinase binding Cellular component cytoplasm cytosol postsynaptic membrane postsynaptic density membrane plasma membrane endocytic vesicle dendritic spine intracellular anatomical structure basolateral plasma membrane clathrin-coated pit cytoplasmic vesicle nucleus intracellular membrane-bounded organelle endosome Biological process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of calcium ion transport regulation of protein phosphorylation negative regulation of interleukin-1 beta production negative regulation of protein kinase B signaling negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of protein kinase B signaling positive regulation of protein phosphorylation endocytosis regulation of G protein-coupled receptor signaling pathway positive regulation of receptor internalization negative regulation of release of cytochrome c from mitochondria negative regulation of interleukin-6 production receptor internalization transcription by RNA polymerase II positive regulation of peptidyl-serine phosphorylation detection of temperature stimulus involved in sensory perception of pain follicle-stimulating hormone signaling pathway platelet activation dopamine receptor signaling pathway negative regulation of protein ubiquitination brain development negative regulation of GTPase activity negative regulation of toll-like receptor signaling pathway protein ubiquitination positive regulation of DNA biosynthetic process positive regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation cell chemotaxis protein transport negative regulation of natural killer cell mediated cytotoxicity regulation of androgen receptor signaling pathway positive regulation of synaptic transmission, dopaminergic negative regulation of tumor necrosis factor production negative regulation of signal transduction positive regulation of protein ubiquitination transforming growth factor beta receptor signaling pathway negative regulation of NF-kappaB transcription factor activity negative regulation of smooth muscle cell apoptotic process desensitization of G protein-coupled receptor signaling pathway by arrestin signal transduction adult walking behavior negative regulation of interleukin-12 production Wnt signaling pathway, planar cell polarity pathway negative regulation of protein phosphorylation G protein-coupled receptor internalization positive regulation of gene expression protein deubiquitination membrane organization positive regulation of cardiac muscle cell differentiation G protein-coupled receptor signaling pathway excitatory postsynaptic potential positive regulation of collagen biosynthetic process negative regulation of neuron apoptotic process positive regulation of epithelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 409 216869 Ensembl ENSG00000141480 ENSMUSG00000060216 UniProt P32121 Q91YI4 RefSeq (mRNA) NM_001257328 NM_001257329 NM_001257330 NM_001257331 NM_004313 NM_199004 NM_001330064 NM_001271358 NM_001271359 NM_001271360 NM_145429 RefSeq (protein) NP_001244257 NP_001244258 NP_001244259 NP_001244260 NP_001316993 NP_004304 NP_945355 NP_001258287 NP_001258288 NP_001258289 NP_663404 Location (UCSC) Chr 17: 4.71 – 4.72 Mb Chr 11: 70.32 – 70.33 Mb PubMed search [3] [4]
Wikidata
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals,^[5][6][7] as well as having signalling roles in their own right.^{[8][9][10][11][12]} Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[13]

The protein may interact with the agonist DOI in 5-HT_2A receptor signaling.^[14][15]

Arrestin beta 2 is crucial for the development of tolerance to morphine and other opioids.