Difosfoinozitol polifosfat-fosfohidrolaza 2 je enzim koji je kod ljudi kodiran genom NUDT4.[5][6][7]
NUDT4 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/f/fa/Protein_NUDT4_PDB_2duk.png/250px-Protein_NUDT4_PDB_2duk.png) |
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Identifikatori |
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Aliasi | NUDT4 |
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Vanjski ID-jevi | OMIM: 609229 MGI: 1918457 HomoloGene: 41726 GeneCards: NUDT4 |
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Ontologija gena |
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Molekularna funkcija | • inositol diphosphate tetrakisphosphate diphosphatase activity • inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity • inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity • inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity • vezivanje iona metala • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje sa RNK • inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity • hydrolase activity • diphosphoinositol-polyphosphate diphosphatase activity • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity • inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity • inositol diphosphate pentakisphosphate diphosphatase activity • inositol bisdiphosphate tetrakisphosphate diphosphatase activity • endopolyphosphatase activity • bis(5'-adenosyl)-hexaphosphatase activity • bis(5'-adenosyl)-pentaphosphatase activity • m7G(5')pppN diphosphatase activity • snoRNA binding
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Ćelijska komponenta | • intracellular anatomical structure • jedro • citoplazma • citosol
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Biološki proces | • GO:0007243 intracellular signal transduction • cyclic nucleotide metabolic process • inositol phosphate metabolic process • cyclic-nucleotide-mediated signaling • calcium-mediated signaling • diphosphoinositol polyphosphate metabolic process • diadenosine pentaphosphate catabolic process • diadenosine hexaphosphate catabolic process • adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
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Izvori:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovjek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNK) | | |
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RefSeq (bjelančevina) | | |
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Lokacija (UCSC) | Chr 12: 93.38 – 93.41 Mb | Chr 10: 95.38 – 95.4 Mb |
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PubMed pretraga | [3] | [4] |
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Wikipodaci |
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Protein kodiran ovim genom regulira promet polifosfat-difosfoinozitola. Promet ovih visokoenergetskih difosfoinozitol-polifosfata predstavlja aktivnost promjene molekula sa važnim regulatornim posljedicama. Molekulskno prebacivanje difosfoinozitol-polifosfata može doprinijeti regulaciji unutarčelijskog prometa. Opisano je nekoliko alternativno prerađenih varijanti transkripta, ali priroda nekih od njih nije utvrđena cijelom dužinom. Izoforme DIPP2alfa i DIPP2beta međusobno se razlikuju samo po tome što DIPP2beta ima jednu dodatnu aminokiselinu zbog pomjeranja granice introna u alternativnoj preradi.[7]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 180 aminokiselina, a molekulska težina 20.306 Da.[8].
10 | | 20 | | 30 | | 40 | | 50 |
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MMKFKPNQTR | | TYDREGFKKR | | AACLCFRSEQ | | EDEVLLVSSS | | RYPDQWIVPG |
GGMEPEEEPG | | GAAVREVYEE | | AGVKGKLGRL | | LGIFENQDRK | | HRTYVYVLTV |
TEILEDWEDS | | VNIGRKREWF | | KVEDAIKVLQ | | CHKPVHAEYL | | EKLKLGCSPA |
NGNSTVPSLP | | DNNALFVTAA | | QTSGLPSSVR |
- Simboli
Reference
Dopunska literatura
Vanjski linkovi