Katepsin B

Katepsin B (EC 3.4.22.1 – katepsin B1 ili katepsin II – je enzim iz superfamilije peptidaza, familija papaina.^{[5][6][7][8][9][10][11][12]} katalizira slijedeću hemijsku reakciju:

Katepsin B
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3PBH, 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M
Identifikatori
Aliasi	CTSB
Vanjski ID-jevi	OMIM: 116810 MGI: 88561 HomoloGene: 37550 GeneCards: CTSB
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek)[1] Bend 8p23.1 Početak 11,842,524 bp[1] Kraj 11,869,448 bp[1]
Lokacija gena (miš) Hrom. Hromosom 14 (miš)[2] Bend 14 D1|14 33.24 cM Početak 63,359,911 bp[2] Kraj 63,383,372 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • cysteine-type peptidase activity • collagen binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 vezivanje za proteine • cysteine-type endopeptidase activity • hydrolase activity • proteoglycan binding • serine-type endopeptidase activity • endopeptidase activity Ćelijska komponenta • intracellular membrane-bounded organelle • Melanosom • intracellular anatomical structure • extracellular region • endolysosome lumen • Jedarce • mitohondrija • Lizozom • Egzosom • perinuklearno područje citoplazme • Vanćelijsko • ficolin-1-rich granule lumen • collagen-containing extracellular matrix Biološki proces • regulation of apoptotic process • epithelial cell differentiation • Proteoliza • toll-like receptor signaling pathway • decidualization • cellular response to thyroid hormone stimulus • collagen catabolic process • viral entry into host cell • GO:0048552 regulation of catalytic activity • proteolysis involved in cellular protein catabolic process • neutrophil degranulation Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1508	13030
Ensembl	ENSG00000164733 ENSG00000285132	ENSMUSG00000021939
UniProt	P07858	P10605
RefSeq (mRNK)	NM_001908 NM_147780 NM_147781 NM_147782 NM_147783 NM_001317237	NM_007798
RefSeq (bjelančevina)	NP_001304166 NP_001899 NP_680090 NP_680091 NP_680092 NP_680093	NP_031824
Lokacija (UCSC)	Chr 8: 11.84 – 11.87 Mb	Chr 14: 63.36 – 63.38 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Hidroliza proteina široke specifičnosti peptidnih veza. Prvenstveno razlaže -Arg- -Arg- veze u malim molekulama supstrata, po čeme se razlikuje od katepsina L.