ESM1

ESM1
Identifikatori
Aliasi	ESM1
Vanjski ID-jevi	OMIM: 601521 MGI: 1918940 HomoloGene: 5107 GeneCards: ESM1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	55,022,671 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	113,354,632 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• integrin binding; • insulin-like growth factor binding; • hepatocyte growth factor receptor binding;
Ćelijska komponenta	• extracellular region;
Biološki proces	• sprouting angiogenesis; • regulation of cell growth; • Angiogeneza; • positive regulation of cell population proliferation; • positive regulation of hepatocyte growth factor receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	11082
	71690
	ENSG00000164283
	ENSMUSG00000042379
	Q9NQ30
	Q9QYY7
	NM_007036; NM_001135604
	NM_023612
	NP_001129076; NP_008967
	NP_076101
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Endotelna ćelijski specifična molekula 1 jest protein koji je kod ljudi kodiran genom ESM1.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 184 aminokiseline, а molekulska težina 20.095 Da.^[7].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKSVLLLTTL	LVPAHLVAAW	SNNYAVDCPQ	HCDSSECKSS	PRCKRTVLDD
CGCCRVCAAG	RGETCYRTVS	GMDGMKCGPG	LRCQPSNGED	PFGEEFGICK
DCPYGTFGMD	CRETCNCQSG	ICDRGTGKCL	KFPFFQYSVT	KSSNRFVSLT
EHDMASGDGN	IVREEVVKEN	AAGSPVMRKW	LNPR

Funkcija

Ovaj gen kodira izlučeni protein koji se uglavnom eksprimira u endotelnim ćelijama u ljudskim plućnim i bubrežnim tkivima. Ekspresiju ovog gena reguliraju citokini, što sugerira da on može imati ulogu u patološkim poremećajima ovisnim o endotelu. Transkript sadrži više signala nestabilnosti poliadenilacije i iRNK.^[6]

Genski proizvod ESM-1 također se naziva endokan, od 2001. godine, kada su ga Bechard et al. okarakterizirali kao dermatan-sulfat proteoglikan. Nedavno su nezavisni timovi opisali endokan/ESM-1 kao specifični biomarker vršnih ćelija tokom neoangiogeneze. Pokazalo se da je ekspresija endokana povećana u prisutnosti proangiogenih faktora rasta, kao što je faktor rasta vaskularnog endotela (VEGF) ili faktor rasta fibroblasta 2 (FGF-2). Kod hipervaskulariziranih karcinoma, imunohistohemijski otkrivena je prekomjerna ekspresija endokana, upotrebom monoklonskih antitijela protiv endokana/ESM-1.

Reference

Dopunska literatura

Bechard D, Meignin V, Scherpereel A, et al. (2000). "Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies". J. Vasc. Res. 37 (5): 417–25. doi:10.1159/000025758. PMID 11025405. S2CID 22931177.
Béchard D, Scherpereel A, Hammad H, et al. (2001). "Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1". J. Immunol. 167 (6): 3099–106. doi:10.4049/jimmunol.167.6.3099. PMID 11544294.
Aitkenhead M, Wang SJ, Nakatsu MN, et al. (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM". Microvascular Research. 63 (2): 159–71. doi:10.1006/mvre.2001.2380. PMID 11866539.
Tsai JC, Zhang J, Minami T, et al. (2002). "Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter". J. Vasc. Res. 39 (2): 148–59. doi:10.1159/000057763. PMID 12011586. S2CID 40049627.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wellner M, Herse F, Janke J, et al. (2004). "Endothelial cell specific molecule-1--a newly identified protein in adipocytes". Horm. Metab. Res. 35 (4): 217–21. doi:10.1055/s-2003-39477. PMID 12778364.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Cong R, Jiang X, Wilson CM, et al. (2006). "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)". Biochem. Biophys. Res. Commun. 346 (2): 535–45. doi:10.1016/j.bbrc.2006.05.153. PMID 16764824.
Grigoriu BD, Depontieu F, Scherpereel A, et al. (2007). "Endocan expression and relationship with survival in human non-small cell lung cancer". Clin. Cancer Res. 12 (15): 4575–82. doi:10.1158/1078-0432.CCR-06-0185. PMID 16899604.
Rennel E, Mellberg S, Dimberg A, et al. (2007). "Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer". Exp. Cell Res. 313 (7): 1285–94. doi:10.1016/j.yexcr.2007.01.021. PMID 17362927.

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ESM1

Sadržaj

Aminokiselinska sekvenca

Funkcija

Reference

Dopunska literatura