APOM

Apoliprotein M
Apoliprotein M
	Trodimrnzijska struktura ljudskog apoliproteina
Identifikatori
Simbol	ApoM

APOM
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2WEW, 2WEX, 2YG2
Identifikatori
Aliasi	APOM
Vanjski ID-jevi	OMIM: 606907 MGI: 1930124 HomoloGene: 10308 GeneCards: APOM
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	31,658,210 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	35,351,026 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• lipid transporter activity; • antioxidant activity; • phospholipid binding;
Ćelijska komponenta	• discoidal high-density lipoprotein particle; • integral component of plasma membrane; • very-low-density lipoprotein particle; • spherical high-density lipoprotein particle; • extracellular region; • low-density lipoprotein particle; • high-density lipoprotein particle; • Vanćelijsko;
Biološki proces	• lipoprotein metabolic process; • lipid transport; • negative regulation of plasma lipoprotein oxidation; • response to glucose; • high-density lipoprotein particle assembly; • retinoid metabolic process; • high-density lipoprotein particle remodeling; • cholesterol efflux; • cholesterol homeostasis; • reverse cholesterol transport; • high-density lipoprotein particle clearance; • cellular oxidant detoxification;
	Izvori:Amigo / QuickGO
Ortolozi
	55937
	55938
ENSG00000231974; ENSG00000204444; ENSG00000206409; ENSG00000227567; ENSG00000235754;
	ENSG00000224290; ENSG00000226215
	ENSMUSG00000024391
	O95445
	Q9Z1R3
	NM_001256169; NM_019101
	NM_018816
	NP_001243098; NP_061974
	NP_061286
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Apolipoprotein M jest protein koji je kod ljudi kodiran genom APOM.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 188 aminokiselina, а molekulska težina 21.253 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MFHQIWAALL	YFYGIILNSI	YQCPEHSQLT	TLGVDGKEFP	EVHLGQWYFI
AGAAPTKEEL	ATFDPVDNIV	FNMAAGSAPM	QLHLRATIRM	KDGLCVPRKW
IYHLTEGSTD	LRTEGRPDMK	TELFSSSCPG	GIMLNETGQG	YQRFLLYNRS
PHPPEKCVEE	FKSLTSCLDS	KAFLLTPRNQ	EACELSNN

Funkcija

Protein kodiran ovim genom je apolipoprotein i član lipokalinske porodice proteina. Utvrđeno je da je povezan sa lipoproteinima velike gustoće i u manjoj mjeri sa lipoproteinima niske gustoće i lipoproteinom bogatim trigliceridima. Kodirani protein se izlučuje kroz plazmamembranu, ali ostaje vezan za membranu, gdje je uključen u transport lipida. Za ovaj gen nađene su dvije varijante transkripta koje kodiraju dvije različite izoforme, ali samo je jedna od njih potpuno okarakterizirana.^[7] Prosječna molekulna težina je 21253 Da, a monoizotopska molekulska masa je 21239 Da.

Reference

Dopunska literatura

Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)". Genomics. 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
Xu N, Zhang XY, Dong X, et al. (2002). "Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells". Biochem. Biophys. Res. Commun. 292 (4): 944–50. doi:10.1006/bbrc.2002.6755. PMID 11944906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang XY, Dong X, Zheng L, et al. (2003). "Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization". Acta Histochem. 105 (1): 67–72. doi:10.1078/0065-1281-00687. PMID 12666989.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Richter S, Shih DQ, Pearson ER, et al. (2004). "Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels". Diabetes. 52 (12): 2989–95. doi:10.2337/diabetes.52.12.2989. PMID 14633861.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Zhang XY, Jiao GQ, Hurtig M, et al. (2005). "Expression pattern of apolipoprotein M during mouse and human embryogenesis". Acta Histochem. 106 (2): 123–8. doi:10.1016/j.acthis.2003.11.004. PMID 15147633.
Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102. S2CID 27752858.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Xu N, Nilsson-Ehle P, Ahrén B (2005). "Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects". J. Nutr. Biochem. 15 (10): 579–82. doi:10.1016/j.jnutbio.2004.03.001. PMID 15542348.
Luo G, Hurtig M, Zhang X, et al. (2005). "Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells". Biochim. Biophys. Acta. 1734 (2): 198–202. doi:10.1016/j.bbalip.2005.02.005. PMID 15904876.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Niu N, Zhu X, Liu Y, et al. (2007). "Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese". Diabetes Metab. Res. Rev. 23 (1): 21–5. doi:10.1002/dmrr.641. PMID 16572495. S2CID 21156244.
Christoffersen C, Nielsen LB, Axler O, et al. (2006). "Isolation and characterization of human apolipoprotein M-containing lipoproteins". J. Lipid Res. 47 (8): 1833–43. doi:10.1194/jlr.M600055-JLR200. PMID 16682745.
Karlsson H, Lindqvist H, Tagesson C, Lindahl M (2006). "Characterization of apolipoprotein M isoforms in low-density lipoprotein". J. Proteome Res. 5 (10): 2685–90. doi:10.1021/pr060180x. PMID 17022639.
Xu X, Ye Q, Xu N, et al. (2007). "Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver". Transplant. Proc. 38 (9): 2769–73. doi:10.1016/j.transproceed.2006.08.133. PMID 17112825.
Ahnström J, Faber K, Axler O, Dahlbäck B (2007). "Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M". J. Lipid Res. 48 (8): 1754–62. doi:10.1194/jlr.M700103-JLR200. PMID 17525477.

Vanjski linkovi

Applied Research on apoM Arhivirano 18. 12. 2014. na Wayback Machine
Lokacija ljudskog genoma APOM i stranica sa detaljima o genu APOM u UCSC Genome Browseru.
O95445

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[7]

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